JoAnn Manson,


As a physician epidemiologist and endocrinologist, I have been actively involved in the design, conduct, and analysis of several large-scale randomized clinical trials and observational studies of cardiovascular disease (CVD) and type 2 diabetes. I have served as Principal Investigator (PI) of the Boston site of the Women’s Health Initiative since study inception in 1993, PI of the CVD component of the Nurses’ Health Study (NHS) since 1999 (current phase focuses on metabolomic predictors of CVD), previously PI of the NHS diabetes grant, dual PI of the large-scale VITamin D and OmegA-3 TriaL (VITAL) since inception, and PI of several other studies. My primary research interests include the role of endogenous and exogenous estrogens in relation to risk of CVD and other chronic diseases, sex differences in CVD and diabetes risk, nutritional interventions and physical activity in reducing cardiometabolic risk, and the role of biochemical, genetic, and metabolomic markers as predictors of chronic disease. As Chief of the Division of Preventive Medicine at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School, I actively participate in the teaching and mentoring of students, trainees, and faculty members.